https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54219 ACTA2), collagen (COL) 1A1 and fibulin-1 (Fbln1) and higher Fbln1 protein deposition after 7 days. Our results show that exposure of lung fibroblasts to fibrotic stiffness activates genes and secreted factors that are part of fibrotic responses and part of the Senescence-associated secretory phenotype (SASP). This overlap may contribute to the creation of a feedback loop whereby fibroblasts create a perpetuating cycle reinforcing progression of a fibrotic response.]]> Tue 13 Feb 2024 11:58:49 AEDT ]]> Regulation of cellular senescence is independent from profibrotic fibroblast-deposited ECM https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48871 Thu 13 Apr 2023 12:47:57 AEST ]]>